EXPRESSION OF GPX4 BY ONCOLYTIC VACCINIA VIRUS CAN SIGNIFICANTLY ENHANCE CD8+T CELL FUNCTION AND ITS IMPACT AGAINST PANCREATIC DUCTAL ADENOCARCINOMA

Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8+T cell function and its impact against pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is currently difficult to treat, even when therapies are Dishwasher ComfortLift End Stopper combined with immune checkpoint blockade (ICB).A novel strategy for immunotherapy would be to maximize the therapeutic potential of oncolytic viruses (OVs), which have been proven to engage the regulation of tumor micr

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A hierarchical overlay network optimisation model for enhancing data transmission performance in blockchain systems

Abstract The network layer plays PROTEIN WATER STRAWBERRY a crucial role in blockchain systems, enabling essential functions such as message broadcasting and data synchronization.Enhancing data transmission structures and methods at this layer is key to improving scalability and addressing performance limitations.Currently, the uneven distribution

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Transcriptome responses of the aphid vector Myzus persicae are shaped by identities of the host plant and the virus

Background: Numerous studies have documented modifications in vector orientation behavior, settling and feeding behavior, and/or fecundity and survival due to virus infection in host plants.These alterations are often expected to enhance virus transmission, which has led to the hypothesis that such effects are vector manipulations by the virus.Howe

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Reading and proclaiming the Birth Narratives from Luke and Matthew: A study in empirical theology amongst curates and their training incumbents employing the SIFT method

Collections Drawing on Jungian psychological type theory, the SIFT method of biblical hermeneutics and liturgical preaching suggests that the reading and proclaiming of scripture reflects the psychological type preferences of the reader and preacher.This thesis is examined amongst two samples of curates and training incumbents (N = 23, 27), serving

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